A serotonin synthesis inhibitor
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Product Type

Biochemicals
Amino Acids

Research Area

Neuroscience

6-fluoro-DL-Tryptophan

Item No. 17643

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-fluoro-tryptophan
CAS Number
7730-20-3
Synonyms
  • DL-6-Fluorotryptophan
  • NSC 9364
Molecular Formula
C11H11FN2O2
Formula Weight
222.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetic Acid (2%): 1 mg/mlMethanol: 0.1 mg/ml
λmax
218 nm
SMILES
FC1=CC2=C(C(CC(N)C(O)=O)=CN2)C=C1
InChi Code
InChI=1S/C11H11FN2O2/c12-7-1-2-8-6(3-9(13)11(15)16)5-14-10(8)4-7/h1-2,4-5,9,14H,3,13H2,(H,15,16)
InChi Key
YMEXGEAJNZRQEH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $49

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    100 mg

    $86

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    250 mg

    $167

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    500 mg

    $255

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    Product Description

    6-fluoro-DL-Tryptophan is a serotonin synthesis inhibitor that is metabolized in the brain and may be useful for tracing pools of neuronal serotonin.1,2 It is used as a competitive inhibitor of tryptophan binding to albumin and can behave as a substrate for the serotonin neural transporter for passage through the blood brain barrier.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chanut, E., Trouvin, J.H., Bondoux, D., et al. Metabolism of 6-fluoro-DL-tryptophan and its specific effects on the rat brain serotoninergic pathway. Biochem. Pharmacol. 45(5), 1049-1057 (1992).

    2. Chanut, E., Bonnet, J.J., Trouvin, J.H., et al. 6-Fluoro-serotonin as a substrate for the neuronal serotonin transporter. J. Neural Transm. Gen. Sect. 96(2), 105-112 (1994).

    3. Chanut, E., Zini, R., Trouvin, J.H., et al. Albumin binding and brain uptake of 6-fluoro-DL-tryptophan: Competition with L-tryptophan. Biochem. Pharmacol. 44(10), 2082-2085 (1992).