An inhibitor of Hsp70
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Apoptozole

Item No. 17675

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[2-[3,5-bis(trifluoromethyl)phenyl]-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl]methyl]-benzamide
CAS Number
1054543-47-3
Synonyms
  • Apoptosis Activator VII
Molecular Formula
C33H25F6N3O3
Formula Weight
625.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 10 mg/ml
λmax
234 nm
SMILES
COC(C=C1)=CC=C1C2=C(C3=CC=C(OC)C=C3)N(CC4=CC=C(C(N)=O)C=C4)C(C5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=N2
InChi Code
InChI=1S/C33H25F6N3O3/c1-44-26-11-7-20(8-12-26)28-29(21-9-13-27(45-2)14-10-21)42(18-19-3-5-22(6-4-19)30(40)43)31(41-28)23-15-24(32(34,35)36)17-25(16-23)33(37,38)39/h3-17H,18H2,1-2H3,(H2,40,43)
InChi Key
ZIMMTPFXOMAJTQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    25 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 µM) that acts by blocking its ATPase activity.1 It does not act on Hsp40, Hsp60, or Hsp90. Apoptozole dose-dependently induces apoptosis in cancer cells (IC50 = 5-7 µM).1 It prevents the association of Hsp70 with apoptotic protease-activating factor 1 and triggers caspase activation in HeLa cells.1 Apoptozole (10 mg/kg, i.p.) prevents the growth of A549, RKO, and HeLa cell xenografts in mice without significant loss of body weight.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ko, S.K., Kim, J., Na, D.C., et al. A small molecule inhibitor of ATPase activity of HSP70 iduces apoptosis and has antitumor activities. Chem. Biol. 22(3), 391-403 (2015).

    2. Ljung, B. Vascular selectivity of felodipine: Experimental pharmacology. J. Cardiovasc. Pharmacol. 15(Suppl 4), S11-S16 (1990).