An agonist for GPR84
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

6-OAU

Item No. 17687

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(octylamino)-2,4(1H,3H)-pyrimidinedione
CAS Number
83797-69-7
Molecular Formula
C12H21N3O2
Formula Weight
239.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.25 mg/mlDMSO: 0.25 mg/ml
λmax
265 nm
SMILES
O=C1NC(NCCCCCCCC)=CC(N1)=O
InChi Code
InChI=1S/C12H21N3O2/c1-2-3-4-5-6-7-8-13-10-9-11(16)15-12(17)14-10/h9H,2-8H2,1H3,(H3,13,14,15,16,17)
InChi Key
PFSWASUQURIOOR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $103

    Add

    5 mg

    $427

    Add

    10 mg

    $702

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    6-OAU is a synthetic agonist for GPR84 (EC50 = 512 nM).1 It has insignificant actions at a panel of 69 other receptors, channels, or transporters.1 6-OAU promotes chemotaxis in human neutrophils (EC50 = 318 nM) and amplifies TNF-α production by LPS-treated U937 macrophages.1 In rats, 6-OAU (1 mg/ml) drives the recruitment of neutrophils and macrophages when injected into a subcutaneous air pouch and raises serum levels of CXCL1 (growth-regulated α protein) when delivered intravenously.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Suzuki, M., Takaishi, S., Nagasaki, M., et al. Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor. The Journal of Biological Chemisty 288(15), 10684-10691 (2013).