A Cdc42 GTPase inhibitor
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CASIN

Item No. 17694

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(2,3,4,9-tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]-ethanol
CAS Number
425399-05-9
Synonyms
  • Pirl1-related Compound 2
Molecular Formula
C20H22N2O
Formula Weight
306.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/ml
λmax
255 nm
SMILES
OCCNC(CCC1)C2=C1C3=CC(C4=CC=CC=C4)=CC=C3N2
InChi Code
InChI=1S/C20H22N2O/c23-12-11-21-19-8-4-7-16-17-13-15(14-5-2-1-3-6-14)9-10-18(17)22-20(16)19/h1-3,5-6,9-10,13,19,21-23H,4,7-8,11-12H2
InChi Key
RXIUMAOXORBRCY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $120

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    10 mg

    $219

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    50 mg

    $1,003

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    Product Description

    CASIN is an indole-based small molecule that inhibits activation of the Cdc42 GTPase (IC50 = 2 µM for inhibiting actin assembly in PIP2-stimulated actin polymerization assays).1 This compound has been used to explore the role of Cdc42 in the division, survival, and differentiation of hematopoietic stem cells.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Peterson, J.R., Lebensohn, A.M., Pelish, H.E., et al. Biochemical suppression of small molecule inhibitors: A new strategy to identify inhibitor targets and signaling pathway components. Chem. Biol. 13(4), 443-452 (2006).

    2. Sakamori, R., Das, S., Yu, S., et al. Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice. J. Clin. Invest. 122(3), 1052-1065 (2012).

    3. Florian, M.C., Dörr, K., Niebel, A., et al. Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell 10(5), 520-530 (2012).