A COX-2 inhibitor
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FK-3311

Item No. 17697

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]-methanesulfonamide
CAS Number
116686-15-8
Synonyms
  • COX-2 Inhibitor V
Molecular Formula
C15H13F2NO4S
Formula Weight
341.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 5 mg/ml
λmax
225, 272 nm
SMILES
FC1=CC(F)=CC=C1OC2=C(NS(C)(=O)=O)C=CC(C(C)=O)=C2
InChi Code
InChI=1S/C15H13F2NO4S/c1-9(19)10-3-5-13(18-23(2,20)21)15(7-10)22-14-6-4-11(16)8-12(14)17/h3-8,18H,1-2H3
InChi Key
DIIYLGZNZGPXRR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $49

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    1 mg

    $86

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    5 mg

    $167

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    10 mg

    $236

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    Product Description

    FK3311 is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID).1,2 FK3311 inhibits LPS-induced thromboxane B2 (TxB2; Item No. 19030) production (IC50 = 316 nM) in vitro and inhibits adjuvant-induced arthritis (ED50 = 0.29 mg/kg) in rats without causing gastrointestinal irritation. FK3311 also alleviates ischemia-repurfusion injury in canine liver and rat lung in vivo.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tsuji, K., Nakamura, K., Konishi, N., et al. Synthesis and pharmacological properties of 2'-phenoxy-methanesulfonanilide derivatives. Chem. Pharm. Bull. (Tokyo) 40(9), 2399-2409 (1992).

    2. Grossman, C.J., Wiseman, J., Lucas, F.S., et al. Inhibition of constitutive and inducible cyclooxygenase activity in human platelets and mononuclear cells by NSAIDs and Cox 2 inhibitors. Inflamm. Res. 44(6), 253-257 (1995).

    3. Sunose, Y., Takeyoshi, I., Ohwada, S., et al. The effect of cyclooxygenase-2 inhibitor FK3311 on ischemia-reperfusion injury in a canine total hepatic vascular exclusion model. J. Am. Coll. Surg. 192(1), 54-62 (2001).

    4. Otani, Y., Takeyoshi, I., Yoshinari, D., et al. Effects of the COX-2 inhibitor FK3311 on ischemia - reperfusion injury in the rat lung. J. Invest. Surg. 20(3), 175-180 (2007).