An inhibitor of dopamine uptake
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GBR 12935 (hydrochloride)

Item No. 17700

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-piperazine, dihydrochloride
CAS Number
67469-81-2
Molecular Formula
C28H34N2O • 2HCl
Formula Weight
487.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2 mg/ml
SMILES
C1(C(OCCN2CCN(CCCC3=CC=CC=C3)CC2)C4=CC=CC=C4)=CC=CC=C1.Cl.Cl
InChi Code
InChI=1S/C28H34N2O.2ClH/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27;;/h1-9,11-12,14-17,28H,10,13,18-24H2;2*1H
InChi Key
NQWRSILGEXNJIT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $75

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    25 mg

    $149

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    50 mg

    $279

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    100 mg

    $520

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    Product Description

    GBR 12935 is an inhibitor of dopamine uptake that binds to the dopamine transporter (Kd = 27.2 nM).1,2 It is selective for the dopamine transporter over the serotonin and norepinephrine transporters (Kds = 940 and 310 nM, respectively).1 In mice, it increases locomotor activity, but not stereotypic behavior, when administered at a dose of 10 mg/kg but induces gnawing at levels similar to other indirect dopamine agonists with an ED50 value of 17.1 mg/kg.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tatsumi, M., Groshan, K., Blakely, R.D., et al. Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur. J. Pharmacol. 340(2-3), 249-258 (1997).

    2. Tirelli, E., and Witkin, J.M. Differential effects of direct and indirect dopamine agonists on the induction of gnawing in C57Bl/6J mice. J. Pharmacol. Exp. Ther. 273(1), 7-15 (1995).

    3. Tolliver, B.K., and Carney, J.M. Comparison of cocaine and GBR 12935: Effects on locomotor activity and stereotypy in two inbred mouse strains. Pharmacol. Biochem. Behav. 48(3), 733-739 (1994).