A calcium channel blocker
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YS-035 (hydrochloride)

Item No. 17705

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dimethoxy-N-methyl-benzeneethanamine, monohydrochloride
CAS Number
89805-39-0
Molecular Formula
C21H29NO4 • HCl
Formula Weight
395.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 5 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
230, 278 nm
SMILES
COC1=C(OC)C=CC(CCN(C)CCC2=CC(OC)=C(OC)C=C2)=C1.Cl
InChi Code
InChI=1S/C21H29NO4.ClH/c1-22(12-10-16-6-8-18(23-2)20(14-16)25-4)13-11-17-7-9-19(24-3)21(15-17)26-5;/h6-9,14-15H,10-13H2,1-5H3;1H
InChi Key
GYBONEHHSUABAO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $53

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    10 mg

    $101

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    50 mg

    $476

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    Product Description

    YS-035 is a verapamil derivative that dose-dependently blocks calcium uptake via Na+/Ca2+ exchange in diverse types of cells (Ki = 28 µM).1 It inhibits calcium uptake by muscle cells, brain synaptosomes, and kidney fibroblasts.1 YS-035 also prevents calcium release from mitochondria induced by Ruthenium Red but not by uncouplers, respiratory inhibitors, or a chelating agent.1 YS-035 is used to characterize the role of calcium currents in smooth muscle and neuronal electrophysiology.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Deana, R., Panato, L., Cancellotti, F.M., et al. Properties of a new calcium ion antagonist on cellular uptake and mitochondrial efflux of calcium ions. Biochem. J. 218, 899-905 (1984).

    2. Kammer, T., Berger, F., Borchard, U., et al. Electrophysiological characterization of class III activity of a verapamil derivative in guinea-pig cardiac tissues. Arzneimittelforschung 43(3), 302-308 (1993).

    3. Mironov, S.L., Langohr, K., and Richter, D.W. Hyperpolarization-activated current, Ih, in inspiratory brainstem neurons and its inhibition by hypoxia. Eur. J. Neurosci. 12(2), 520-526 (2000).