A synthetic 1,25-dihydroxy vitamin D2 analog
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Paricalcitol

Item No. 17716

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-1,3-cyclohexanediol
CAS Number
131918-61-1
Synonyms
  • 1α,25-Dihydroxy-19-nor-vitamin D2
  • 19-nor-1,25-Dihydroxyvitamin D2
  • Zemplar
Molecular Formula
C27H44O3
Formula Weight
416.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Ethanol: 1 mg/ml
λmax
243, 251, 261 nm
SMILES
O[C@@H](C[C@H](O)C/1)CC1=C\C=C2CCC[C@@]3(C)[C@@]/2([H])CC[C@]3([H])[C@H](C)/C=C/[C@H](C)C(C)(O)C
InChi Code
InChI=1S/C27H44O3/c1-18(8-9-19(2)26(3,4)30)24-12-13-25-21(7-6-14-27(24,25)5)11-10-20-15-22(28)17-23(29)16-20/h8-11,18-19,22-25,28-30H,6-7,12-17H2,1-5H3/b9-8+,21-11+/t18-,19+,22-,23-,24-,25+,27-/m1/s1
InChi Key
BPKAHTKRCLCHEA-UBFJEZKGSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    500 µg

    $108

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    1 mg

    $205

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    5 mg

    $856

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    Product Description

    Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction.1,2,3 Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brown, A.J., Finch, J., Takahashi, F., et al. Calcemic activity of 19-nor-1,25(OH)2D2 decreases with duration of treatment. J. Am. Soc. Nephrol. 11(11), 2088-2094 (2000).

    2. Donate-Correa, J., Domínguez-Pimentel, V., Muros-de-Fuentes, M., et al. Beneficial effects of selective vitamin D receptor activation by paricalcitol in chronic kidney disease. Curr. Drug Targets 15(7), 703-709 (2014).

    3. Walf, M., and Thadhani, R. Vitamin D in patients with renal failure: A summary of observational mortality studies and steps moving forward. J. Steroid Biochem. Mol. Biol. 103(3-5), 487-490 (2007).

    4. Duplancic, D., Cesarik, M., Poljak, N.K., et al. The influence of selective vitamin D receptor activator paricalcitol on cardiovascular system and cardiorenal protection. Clin. Interv. Aging 8, 149-156 (2013).