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An autophagy inhibitor
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Technical Information
Formal Name
6-chloro-1,2,3,4-tetrahydro-N-[2-(4-methyl-1-piperazinyl)ethyl]-9-acridinamine
CAS Number
1411646-44-0
Molecular Formula
C20H27ClN4
Formula Weight
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 5 mg/ml
λmax
226, 252, 330 nm
SMILES
ClC1=CC=C2C(N=C(CCCC3)C3=C2NCCN4CCN(C)CC4)=C1
InChi Code
InChI=1S/C20H27ClN4/c1-24-10-12-25(13-11-24)9-8-22-20-16-4-2-3-5-18(16)23-19-14-15(21)6-7-17(19)20/h6-7,14H,2-5,8-13H2,1H3,(H,22,23)
InChi Key
AKZZUONQDIGIBX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Product Description
Quinacrine analog 34 is an inhibitor of autophagy with a minimum effective concentration (MEC) of 0.5 µM in U2OS cells.1 It induces lysosomal deacidification and accumulation of LC3-II in the same cells when used at concentrations of 0.5 or 3 µM.
WARNING This product is not for human or veterinary use.
References & Product Citations
Product Description References
1. Synthesis of improved lysomotropic autophagy inhibitors. J. Med. Chem. 58(7), 3025-3035 (2015).
Contact Info
Cayman Chemical1180 East Ellsworth RoadAnn Arbor, Michigan 48108 USAToll Free: (800) 364-9897(USA and Canada only)Fax: (734) 971-3640
