A selective PAR2 agonist
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AC-55541

Item No. 17736

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid 2E-[1-(3-bromophenyl)ethylidene]hydrazide
CAS Number
916170-19-9
Molecular Formula
C25H20BrN5O3
Formula Weight
518.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMF:PBS (pH 7.2) (1:8): 0.11 mg/mlDMSO: 10 mg/ml
λmax
255, 279 nm
SMILES
O=C1C2=CC=CC=C2C(C(NC(C3=CC=CC=C3)=O)C(N/N=C(C)/C4=CC=CC(Br)=C4)=O)=NN1
InChi Code
InChI=1S/C25H20BrN5O3/c1-15(17-10-7-11-18(26)14-17)28-31-25(34)22(27-23(32)16-8-3-2-4-9-16)21-19-12-5-6-13-20(19)24(33)30-29-21/h2-14,22H,1H3,(H,27,32)(H,30,33)(H,31,34)/b28-15+
InChi Key
UCUHFWIFSHROPY-RWPZCVJISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    AC-55541 is a proteinase-activated receptor 2 (PAR2) agonist that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation.1 It stimulates cell proliferation, phosphatidylinositol hydrolysis, and calcium mobilization in in vitro functional assays (pEC50s = 6.7, 5.9, and 6.6, respectively).1 Intrapaw administration of 3-10 mg/kg AC-55541 elicited pronociceptive activity in vivo.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gardell, L.R., Ma, J.N., Seitzberg, J.G., et al. Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J. Pharmacol. Exp. Ther. 327(3), 799-808 (2008).