A antagonist of CXCL chemokine expression
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Product Type

Biochemicals

Research Area

Cancer
Angiogenesis

UNBS5162

Item No. 17739

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[2-(dimethylamino)ethyl]-2,3-dihydro-1,3-dioxo-1H-benz[de]isoquinolin-5-yl]-urea
CAS Number
956590-23-1
Molecular Formula
C17H18N4O3
Formula Weight
326.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 2 mg/ml
λmax
226, 249, 339, 384 nm
SMILES
O=C(C1=CC(NC(N)=O)=CC2=C1C3=CC=C2)N(CCN(C)C)C3=O
InChi Code
InChI=1S/C17H18N4O3/c1-20(2)6-7-21-15(22)12-5-3-4-10-8-11(19-17(18)24)9-13(14(10)12)16(21)23/h3-5,8-9H,6-7H2,1-2H3,(H3,18,19,24)
InChi Key
WCKZRLOUKYFJDY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

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    25 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    UNBS5162 is a naphthalimide that antagonizes the expression of CXCL chemokines. In vitro exposure of PC-3 prostate cancer cells to 1 µM UNBS5162 for five successive days was shown to decrease the expression of proangiogenic CXCL chemokines.1 UNBS5162 also demonstrates antiangiogenic properties in vivo in an orthotopic PC-3 model.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mijatovic, T., Mahieu, T., Bruyère, C., et al. UNBS5162, a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers. Neoplasia 10(6), 573-586 (2008).