An uncompetitive inhibitor of Epac1
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

CE3F4

Item No. 17767

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,7-dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde
CAS Number
143703-25-7
Molecular Formula
C11H10Br2FNO
Formula Weight
351.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.09 mg/mlEthanol: 5 mg/ml
λmax
220, 294 nm
SMILES
O=C([H])N1C(C)CCC2=C(Br)C(F)=C(Br)C=C21
InChi Code
InChI=1S/C11H10Br2FNO/c1-6-2-3-7-9(15(6)5-16)4-8(12)11(14)10(7)13/h4-6H,2-3H2,1H3
InChi Key
ZZLQPWXVZCPUGC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $86

    Add

    10 mg

    $161

    Add

    50 mg

    $676

    Add
    Product Description

    CE3F4 is an uncompetitive inhibitor of Epac1 activity toward its effector Rap1 in vitro (IC50 = 23 µM) and in cells.1,2. It has no effect on PKA activity. CE3F4 blocks Epac1-induced autophagy in cardiomyocytes stimulated with isoprenaline and blocks the activation of transient receptor potential canonical (TRPC) channels by the Epac activator 8-pCPT.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Courilleau, D., Bisserier, M., Jullian, J.C., et al. Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac. The Journal of Biological Chemisty 287(53), 44192-44202 (2012).

    2. Brown, L.M., Rogers, K.E., McCammon, J.A., et al. Identification and validation of modulators of exchange protein activated by cAMP (Epac) activity: Structure-function implications for Epac activation and inhibition. The Journal of Biological Chemisty 289(12), 8217-8230 (2014).

    3. Laurent, A.C., Bisserier, M., Lucas, A., et al. Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy. Cardiovasc. Res. 105(1), 55-64 (2015).

    4. Domínguez-Rodríguez, A., Ruiz-Hurtado, G., Sabourin, J., et al. Proarrhythmic effect of sustained EPAC activation on TRPC3/4 in rat ventricular cardiomyocytes. J. Mol. Cell. Cardiol. 87, 74-78 (2015).