A PDI inhibitor
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16F16

Item No. 17770

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-1H-pyrido[3,4-b]indole-1-carboxylic acid, methyl ester
CAS Number
922507-80-0
Molecular Formula
C16H17ClN2O3
Formula Weight
320.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/mLDMSO: 10 mg/ml
SMILES
O=C(CCl)N1C(C(OC)=O)(C)C2=C(C(C=CC=C3)=C3N2)CC1
InChi Code
InChI=1S/C16H17ClN2O3/c1-16(15(21)22-2)14-11(7-8-19(16)13(20)9-17)10-5-3-4-6-12(10)18-14/h3-6,18H,7-9H2,1-2H3
InChi Key
BCSIRYFYAKLJDK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $43

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    5 mg

    $190

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    10 mg

    $333

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    25 mg

    $726

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    Product Description

    16F16 is a protein disulfide isomerase (PDI) inhibitor.1 It inhibits PDI reductase activity in an enzyme assay when used at concentrations ranging from 1 to 100 µg/ml.1 16F16 reduces PC12 cell apoptosis induced by the misfolded huntingtin protein HTTQ103. It suppresses PDI-dependent mitochondrial outer membrane permeabilization (MOMP) in isolated PC12 cell mitochondria. 16F16 (2, 3, 4, and 10 µM) reduces HTTN90Q73 mutant huntingtin-induced medium spinal neuron death and MOMP in rat corticostriatal slices. It also reduces pyramidal neuron death induced by amyloid-β precursor protein (APP) in rat corticostriatal slices.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hoffstrom, B.G., Kaplan, A., Letso, R., et al. Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins. Nat. Chem. Biol. 6(12), 900-906 (2010).