A diacylglycerol acyltransferase inhibitor
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Amidepsine D

Item No. 17775

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(2,4-dimethoxy-6-methylbenzoyl)oxy]-2-hydroxy-6-methyl-benzoic acid, 4-carboxy-3-hydroxy-5-methylphenyl ester
CAS Number
79786-34-8
Molecular Formula
C26H24O10
Formula Weight
496.5
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
OC1=C(C(O)=O)C(C)=CC(OC(C2=C(O)C=C(OC(C3=C(C)C=C(OC)C=C3OC)=O)C=C2C)=O)=C1
InChi Code
InChI=1S/C26H24O10/c1-12-7-16(9-18(27)21(12)24(29)30)35-25(31)22-13(2)8-17(10-19(22)28)36-26(32)23-14(3)6-15(33-4)11-20(23)34-5/h6-11,27-28H,1-5H3,(H,29,30)
InChi Key
KODVVMZOLYYCMV-UHFFFAOYSA-N
Origin
Fungi/Humicola sp. FO-2942
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $303

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    2.5 mg

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    Product Description

    Amidepsine D is a fungal metabolite isolated from the culture broth of Humicola sp. FO-2942 that inhibits DGAT activity (IC50 = 17.5 µM in rat liver microsomes).1 It inhibits triacylglycerol formation in Raji cells with an IC50 value of 2.8 µM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tomoda, H., Ito, M., Tabata, N., et al. Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties. J. Antibiot. (Tokyo) 48(9), 937-941 (1995).