A smoothened antagonist
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ALLO-1

Item No. 17776

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(4-chlorophenyl)-5-methyl-1-(phenylmethyl)-2,4-imidazolidinedione
CAS Number
37468-32-9
Molecular Formula
C17H15ClN2O2
Formula Weight
314.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 20 mg/ml
λmax
220 nm
SMILES
O=C1N(C2=CC=C(Cl)C=C2)C(N(CC3=CC=CC=C3)C1C)=O
InChi Code
InChI=1S/C17H15ClN2O2/c1-12-16(21)20(15-9-7-14(18)8-10-15)17(22)19(12)11-13-5-3-2-4-6-13/h2-10,12H,11H2,1H3
InChi Key
GHAJNZREWTZYQJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $108

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    10 mg

    $196

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    25 mg

    $437

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    Product Description

    ALLO-1 is a SMO antagonist that inhibits both wild-type (IC50 = 50 nM) and mutant SMO, including the D473H SMO mutant (IC50s = 300-1000 nM).1 This compound binds to the SMO cysteine-rich domain, which is a different mechanism of interaction compared to other known SMO ligands that bind the transmembrane pocket.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tao, H., Jin, Q., koo, D.I., et al. Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened. Chem. Biol. 18, 432-437 (2011).

    2. Sharpe, H.J., Wang, W., Hannoush, R.N., et al. Regulation of the oncoprotein Smoothened by small molecules. Nat. Chem. Biol. 11, 246-255 (2015).