A selective adenylyl cyclase 5 inhibitor
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NKY80

Item No. 17777

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-7-(2-furanyl)-7,9-dihydro-5(6H)-quinazolinone
CAS Number
299442-43-6
Synonyms
  • Adenylyl Cyclase Type V Inhibitor
Molecular Formula
C12H11N3O2
Formula Weight
229.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 10 mg/mlEthanol: 0.25 mg/ml
λmax
276 nm
SMILES
NC(N=C1)=NC2=C1C(CC(C3=CC=CO3)C2)=O
InChi Code
InChI=1S/C12H11N3O2/c13-12-14-6-8-9(15-12)4-7(5-10(8)16)11-2-1-3-17-11/h1-3,6-7H,4-5H2,(H2,13,14,15)
InChi Key
SOJUSNIBPPMLCC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $81

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    10 mg

    $152

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    25 mg

    $357

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    50 mg

    $633

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    Product Description

    NKY80 is a cell-permeable inhibitor of adenylyl cyclase (AC) that is selective for isoform AC5 over AC2 and AC3 (IC50s = 8.3 μM, 1.7 mM, and 132 μM, respectively in the presence of Gsα GTPγS-forskolin).1 It is a non-competitive inhibitor with respect to ATP (Item No. 14498) and forskolin (Item No. 11018) and tissue selective for AC catalytic activity in heart and lung.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Onda, T., Hashimoto, Y., Nagai, M., et al. Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms. The Journal of Biological Chemisty 276(51), 47785-27793 (2001).