A muscarinic receptor agonist
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Cevimeline (hydrochloride)

Item No. 17802

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2’R,3R)-rel-2’-methyl-spiro[1-azabicyclo[2.2.2]octane-3,5’-[1,3]oxathiolane], monohydrochloride
CAS Number
107220-28-0
Synonyms
  • AF 102B
  • SNI 2011
  • SNK 508
Molecular Formula
C10H17NOS • HCl
Formula Weight
235.8
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 5 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
C[C@@H](SC1)O[C@@]21CN3CCC2CC3.Cl
InChi Code
InChI=1S/C10H17NOS.ClH/c1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11;/h8-9H,2-7H2,1H3;1H/t8-,10-;/m1./s1
InChi Key
SURWTGAXEIEOGY-GHXDPTCOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $108

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    10 mg

    $178

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    Product Description

    Cevimeline is a muscarinic receptor agonist (EC50s = 23, 48, and 63 nM for M1, M3, and M5, respectively, and >1 µM for M2 and M4).1 It stimulates secretion by salivary glands and is useful in ameliorating xerostomia (dry mouth).2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Heinrich, J.N., Butera, J.A., Carrick, T., et al. Pharmacological comparison of muscarinic ligands: Historical versus more recent muscarinic M1-preferring receptor agonists. Eur. J. Pharmacol. 605(1-3), 53-56 (2009).

    2. Kahn, S.T., and Johnstone, P.A. Management of xerostomia related to radiotherapy for head and neck cancer. Oncology (Williston Park) 19(14), 1827-1832 (2005).

    3. Ramos-Casals, M., Tzioufas, A.G., Stone, J.H., et al. Treatment of primary Sjögren syndrome: A systematic review. JAMA 304(4), 452-460 (2010).