An inhibitor of Ras/Rac transformation
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SCH 51344

Item No. 17804

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[2-[(6-methoxy-3-methyl-1H-pyrazolo[3,4-b]quinolin-4-yl)amino]ethoxy]-ethanol
CAS Number
171927-40-5
Synonyms
  • Ras/Rac Transformaton Blocker
Molecular Formula
C16H20N4O3
Formula Weight
316.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 0.25 mg/ml
λmax
245, 305, 385, 405 nm
SMILES
CC1=NNC2=NC3=CC=C(OC)C=C3C(NCCOCCO)=C21
InChi Code
InChI=1S/C16H20N4O3/c1-10-14-15(17-5-7-23-8-6-21)12-9-11(22-2)3-4-13(12)18-16(14)20-19-10/h3-4,9,21H,5-8H2,1-2H3,(H2,17,18,19,20)
InChi Key
YWEGXZZAORIRQR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    50 mg

    $853

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    Cayman Chemical
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    Product Description

    SCH 51344 is a pyrazolo-quinoline derivative that inhibits Ras-induced malignant transformation and prevents anchorage-independent growth of oncogene transformed fibroblasts.1 At 5-25 µM, it has been shown to dose-dependently block Ras/Rac-induced membrane ruffling in REF-52 fibroblasts with little effect on Ras-induced ERK and JNK kinase activity.2 SCH 51344 is also reported to be a potent inhibitor of human mutT homolog MTH1, a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (Kd = 49 nM).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kumar, C.C., Prorock-Rogers, C., Kelly, J., et al. SCH 51344 inhibits ras transformation by a novel mechanism. Cancer Res. 55(21), 5106-5117 (1995).

    2. Walsh, A.B., Dhanasekaran, M., Bar-Sagi, D., et al. SCH 51344-induced reversal of RAS-transformation is accompanied by the specific inhibition of the RAS and RAC-dependent cell morphology pathway. Oncogene 15(21), 2553-2560 (1997).

    3. Huber, K.V.M., Salah, E., Radic, B., et al. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature 508(7495), 222-227 (2014).