Pricing updated 2019-07-18. Prices are subject to change without notice.
Respiratory syncytial virus (RSV) is the leading cause of respiratory tract infections in humans. RSV F protein, which mediates fusion of the viral envelope with the host cell membrane, has become a target of anti-RSV treatment. VP-14637 is a small molecule inhibitor of RSV that demonstrates antiviral activity with an EC50 value of 1.4 nM.1,2 It interferes directly with RSV fusion (EC50 = 5.4 nM), binding to the viral F protein, which allows simultaneous interaction with both of the heptad repeat domains of the F protein trimer.1,2
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Douglas, J.L., Panis, M.L., Ho, E., et al. Inhibition of respiratory syncytial virus fusion by the small molecule VP-
Douglas, J.L., Panis, M.L., Ho, E., et al. Small molecules VP-