An RSV inhibitor
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VP-14637

Item No. 17805

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2’-[(4-hydroxyphenyl)methylene]bis[4-[[(5-methyl-1H-tetrazol-1-yl)imino]methyl]-phenol
CAS Number
235106-62-4
Molecular Formula
C25H22N10O3
Formula Weight
510.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml
λmax
238, 326 nm
SMILES
OC1=CC=C(C(C2=CC(/C=N/N3C(C)=NN=N3)=CC=C2O)C4=CC(/C=N\N5N=NN=C5C)=CC=C4O)C=C1
InChi Code
InChI=1S/C25H22N10O3/c1-15-28-30-32-34(15)26-13-17-3-9-23(37)21(11-17)25(19-5-7-20(36)8-6-19)22-12-18(4-10-24(22)38)14-27-35-16(2)29-31-33-35/h3-14,25,36-38H,1-2H3/b26-13-,27-14+
InChi Key
BLUJRJMLDHEMRX-VVCLLGATSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    10 mg

    $393

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    Cayman Chemical
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    Product Description

    VP-14637 is a small molecule inhibitor of RSV that demonstrates antiviral activity with an EC50 value of 1.4 nM.1,2 It interferes directly with RSV fusion (EC50 = 5.4 nM), binding to the viral F protein, which allows simultaneous interaction with both of the heptad repeat domains of the F protein trimer.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Douglas, J.L., Panis, M.L., Ho, E., et al. Inhibition of respiratory syncytial virus fusion by the small molecule VP-14637 via specific interactions with F protein. J. Virol. 77(9), 5054-5064 (2003).

    2. Douglas, J.L., Panis, M.L., Ho, E., et al. Small molecules VP-14637 and JNJ-2408068 inhibit respiratory syncytial virus fusion by similar mechanisms. Antimicrob. Agents Chemother. 49(6), 2460-2466 (2005).