A cell-permeable form of cyclic PFT-α
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p-nitro-Cyclic Pifithrin-α

Item No. 17848

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,6,7,8-tetrahydro-2-(4-nitrophenyl)-imidazo[2,1-b]benzothiazole
CAS Number
60477-38-5
Synonyms
  • Cyclic pifithrin-α-p-nitro
  • p-nitro-Cyclic PFT-α
Molecular Formula
C15H13N3O2S
Formula Weight
299.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/ml
λmax
234, 349 nm
SMILES
O=[N+](C(C=C1)=CC=C1C2=CN(C(S3)=N2)C4=C3CCCC4)[O-]
InChi Code
InChI=1S/C15H13N3O2S/c19-18(20)11-7-5-10(6-8-11)12-9-17-13-3-1-2-4-14(13)21-15(17)16-12/h5-9H,1-4H2
InChi Key
XMFNSEDROOHGBY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $41

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    p-nitro-Cyclic PFT-α is a cell-permeable form of cyclic PFT-α.1 It is one order of magnitude more active that PFT-α in protecting cortical neurons exposed to etoposide (ED50 = 30 nM).1 p-nitro-Cyclic PFT-α acts in a p53-dependent manner but does not block phosphorylation of p53 on Ser15 in response to etoposide treatment, although it prevents p53 posttranscriptional activity.1 Although it is more stable in solution than the parent compound, this derivative is not active in vivo.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pietrancosta, N., Moumen, A., Dono, R., et al. Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: Discovery of a highly potent in vivo inhibitor and its action mechanism. J. Med. Chem. 49(12), 3645-3652 (2006).