An alcohol dehydrogenase inhibitor
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Fomepizole

Item No. 17851

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-methyl-1H-pyrazole
CAS Number
7554-65-6
Synonyms
  • 4-Methylpyrazole
Molecular Formula
C4H6N2
Formula Weight
82.1
Purity
≥98%
Formulation
A neat oil
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
220 nm
SMILES
CC1=CNN=C1
InChi Code
InChI=1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)
InChi Key
RIKMMFOAQPJVMX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 mg

    $50

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    1 g

    $70

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    5 g

    $273

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    10 g

    $495

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    Product Description

    Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes metabolism of ethylene glycol and methanol to toxic metabolites.1 At 10 µM in monkeys, it can prevent the formation of toxic alcohol metabolites that generate metabolic acidosis.1 This compound is typically used as an antidote for ethylene glycol or methanol poisoning.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Blomstrand, R., Östling-Wintzell, H., Löf, A., et al. Pyrazoles as inhibitors of alcohol oxidation and as important tools in alcohol research: An approach to therapy against methanol poisoning. Proc. Natl. Acad. Sci. USA 76(7), 3499-3503 (1979).

    2. Brent, J., McMartin, K., Phillips, S., et al. Fomepizole for the treatment of methanol poisoning. N. Engl. J. Med. 344, 424-429 (2001).