An interferon-inducing antiviral agent
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Biochemicals

Research Area

Immunology & Inflammation
Neuroscience

Tilorone (hydrochloride)

Item No. 17868

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,7-bis[2-(diethylamino)ethoxy]-9H-fluoren-9-one, dihydrochloride
CAS Number
27591-69-1
Synonyms
  • NSC 143969
Molecular Formula
C25H34N2O3 • 2HCl
Formula Weight
483.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
268 nm
SMILES
CCN(CC)CCOC1=CC=C(C(C=CC(OCCN(CC)CC)=C2)=C2C3=O)C3=C1.Cl.Cl
InChi Code
InChI=1S/C25H34N2O3.2ClH/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19;;/h9-12,17-18H,5-8,13-16H2,1-4H3;2*1H
InChi Key
BSVYJQAWONIOOU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $41

    Add

    100 mg

    $75

    Add

    500 mg

    $255

    Add

    1 g

    $389

    Add
    Product Description

    Tilorone is an orally active, antiviral compound that induces interferon production and is reported to have antitumor, anti-inflammatory, and neuroprotective actions.1,2,3 With chronic administration, tilorone induces lysosomal glycosaminoglycan storage, rendering glycosaminoglycans resistant to enzymatic degradation.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stringfellow, D.A., and Glasgow, L.A. Tilorone hydrochloride: An oral interferon-inducing agent. Antimicrob. Agents Chemother. 2(2), 73-78 (1972).

    2. Wissing, M.D., Dadon, T., Kim, E., et al. Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression. Oncol. Rep. 32, 419-424 (2014).

    3. Ratan, R.R., Siddiq, A., Aminova, L., et al. Small molecule activation of adaptive gene expression: Tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury. Ann. N. Y. Acad. Sci. 1147, 383-394 (2011).

    4. Fischer, J. Tilorone-induced lysosomal storage of glycosaminoglycans in cultured corneal fibroblasts: Biochemical and physicochemical investigations. Biochem. J. 312, 215-222 (1995).