A fluorescent molecular rotor
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CCVJ

Item No. 17870

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-cyano-3-(2,3,6,7-tetrahydro-1H,5H-benzo[ij]quinolizin-9-yl)-2-propenoic acid
CAS Number
142978-18-5
Synonyms
  • ​9-(2-Carboxy-2-cyanovinyl)julolidine​
Molecular Formula
C16H16N2O2
Formula Weight
268.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 10 mg/ml
λmax
279, 441 nm
SMILES
OC(/C(C#N)=C/C1=CC(CCC2)=C(N2CCC3)C3=C1)=O
InChi Code
InChI=1S/C16H16N2O2/c17-10-14(16(19)20)9-11-7-12-3-1-5-18-6-2-4-13(8-11)15(12)18/h7-9H,1-6H2,(H,19,20)/b14-9+
InChi Key
JXENNHTVELFRHV-NTEUORMPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $40

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    5 mg

    $132

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    10 mg

    $207

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    Product Description

    CCVJ is a fluorescent molecular rotor characterized by low background fluorescence, low fluorescence anisotropy, and good water solubility.1,2,3,4 Moreover, CCVJ has large hydrophobic structures, allowing it to associate in a non-covalent manner with hydrophobic pockets in proteins in solution.1 CCVJ is broadly used to monitor changes in solution and molecular characteristics.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Haidekker, M.A., Nipper, M., Mustafic, A., et al. Dyes with segmental mobility: Molecular rotors. Advanced Fluorescence Reporters in Chemistry and Biology I: Fundamentals and Molecular Design 267-308 (2010).

    2. Hawe, A., Filipe, V., and Jiskoot, W. Fluorescent molecular rotors as dyes to characterize polysorbate-containing IgG formulations. Pharmacol. Res. 27(2), 314-326 (2010).

    3. Ablinger, E., Leitgeb, S., and Zimmer, A. Differential scanning fluorescence approach using a fluorescent molecular rotor to detect thermostability of proteins in surfactant-containing formulations. Int. J. Pharm. 441(1-2), 255-260 (2013).

    4. Levitt, J.A., Chung, P.H., Kuimova, M.K., et al. Fluorescence anisotropy of molecular rotors. Chemphyschem. 12(3), 662-672 (2011).