An NSAID and COX-1 inhibitor
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Labeled Version(s)
34009Pranoprofen-13C-d3
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Pranoprofen

Item No. 17875

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-methyl-5H-[1]benzopyrano[2,3-b]pyridine-7-acetic acid
CAS Number
52549-17-4
Synonyms
  • Pyranoprofen
  • Y 8004
Molecular Formula
C15H13NO3
Formula Weight
255.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/ml
λmax
247, 276 nm
SMILES
OC(C(C)C1=CC(CC2=CC=CN=C2O3)=C3C=C1)=O
InChi Code
InChI=1S/C15H13NO3/c1-9(15(17)18)10-4-5-13-12(7-10)8-11-3-2-6-16-14(11)19-13/h2-7,9H,8H2,1H3,(H,17,18)
InChi Key
TVQZAMVBTVNYLA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 mg

    $36

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    100 mg

    $68

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    250 mg

    $132

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    1 g

    $395

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    Product Description

    Pranoprofen is a non-steroidal anti-inflammatory drug (NSAID) and COX-1 inhibitor (IC50 = 3.1 µM).1,2 It decreases B. pertussis-induced production of prostaglandin E2 (PGE2; Item No. 14010) in isolated rat peritoneal leukocytes (IC50 = 0.39 µM).2 Ocular application of pranoprofen reduces corneal epithelial damage in a mouse model of corneal alkali burns.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, M., Gureeye, A., Cissé, Y., et al. The therapeutic effects and possible mechanism of pranoprofen in mouse model of corneal alkali burns. J. Ophthalmol. 7485912 (2020).

    2. Naka, Y., Yamada, I., Ochi, H., et al. Structural optimization of alkyl-substituted 2-(7-5H-[1]benzopyrano[2,3-b]pyridyl)propionic acid as anti-inflammatory agents. Bioorg. Med. Chem. Lett. 5(9), 959-962 (1995).