A chloride channel inhibitor
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IAA-94

Item No. 17877

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(2R)-6,7-dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl]oxy]-acetic acid
CAS Number
54197-31-8
Synonyms
  • R(+)-IAA-94
Molecular Formula
C17H18Cl2O4
Formula Weight
357.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 15 mg/mlEthanol: 15 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
224, 269, 306 nm
SMILES
ClC1=C(C([C@](C2CCCC2)(C)C3)=O)C3=CC(OCC(O)=O)=C1Cl
InChi Code
InChI=1S/C17H18Cl2O4/c1-17(10-4-2-3-5-10)7-9-6-11(23-8-12(20)21)14(18)15(19)13(9)16(17)22/h6,10H,2-5,7-8H2,1H3,(H,20,21)/t17-/m1/s1
InChi Key
RNOJGTHBMJBOSP-QGZVFWFLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $90

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    10 mg

    $157

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    25 mg

    $341

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    Product Description

    IAA-94 is an indanyloxyacetic acid (IAA) inhibitor of chloride channels that binds channels in bovine kidney cortex microsomes with a Ki value of 1 µM.1 At 10 µM, it also reversibly inhibits chloride intracellular channel proteins, which have both soluble and membrane-bound activities.2,3 IAA-94 is used to study the properties of chloride channels in a variety of preparations.4,5,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Landry, D.W., Reitman, M., Cragoe, E.J., Jr., et al. Epithelial chloride channel. Development of inhibitory ligands. J. Gen. Physiol. 90, 779-798 (1987).

    2. Valenzuela, S.M., Mazzanti, M., Tonini, R., et al. The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle. J. Physiol. 529.3, 541-552 (2000).

    3. Khamici, H.A., Brown, L.J., Hossain, K.R., et al. Memebers of the chloride intracellular ion channel protein family demonstrate glutaredoxin-like enzymatic activity. PLoS One 10(1), 1-19 (2015).

    4. Costa, J.A., Nguyen, D.A., Leal-Pinto, E., et al. Wicking: A rapid method for manually inserting ion channels into planar lipid bilayers. PLoS One 8(5), 1-9 (2013).

    5. Liskova, S., Petrova, M., Karen, P., et al. Contribution of Ca2+-dependent Cl- channels to norepinephrine-induced contraction of femoral artery is replaced by increasing EDCF contribution during ageing. Biomed. Res. Int. 289361, 1-9 (2014).