A ligand for glucosidase purification
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N-5-Carboxypentyl-1-deoxynojirimycin

Item No. 17878

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3R,4R,5S-trihydroxy-2R-(hydroxymethyl)-1-piperidinehexanoic acid
CAS Number
79206-51-2
Synonyms
  • N-5-Carboxypentyl-1-DNJ
  • N-5-Carboxypentyl-1-dNM
Molecular Formula
C12H23NO6
Formula Weight
277.3
Purity
≥95%
Formulation
A crystalline solid
SMILES
O[C@H]1[C@H](O)[C@@H](CO)N(CCCCCC(O)=O)C[C@@H]1O
InChi Code
InChI=1S/C12H23NO6/c14-7-8-11(18)12(19)9(15)6-13(8)5-3-1-2-4-10(16)17/h8-9,11-12,14-15,18-19H,1-7H2,(H,16,17)/t8-,9+,11-,12-/m1/s1
InChi Key
KTNVTDIFZTZBJY-RBLKWDMZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $75

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    5 mg

    $241

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    Product Description

    N-5-Carboxypentyl-1-deoxynojirimycin is a ligand used for the purification of glucosidase I and II.1,2 The carboxypentyl groups allows linkage of the inhibitor with resins for affinity chromatography.1,3 N-5-Carboxypentyl-1-deoxynojirimycin is at least as potent an inhibitor of glucosidase as 1-deoxynojirimycin (Kis = 0.45 and 2.1 µM, respectively, for pig liver glucosidase I).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bause, E., Gross, A., and Schweden, J. N-Methyl-N-(5-carboxypentyl)-1-deoxynojirimycin, a new affinity ligand for the purification of trimming glucosidase I. FEBS Lett. 278(2), 167-170 (1991).

    2. Hentges, A., and Bause, E. Affinity purification and characterization of glucosidase II from pig liver. Biol. Chem. 378(9), 1031-1038 (1997).

    3. Bernotas, R.C., and Ganem, B. Easy assembly of ligands for glycosidase affinity chromatography. Biochem. J. 270(2), 539-540 (1990).

    4. Bause, E., Schweden, J., Gross, A., et al. Purification and characterization of trimming glucosidase I from pig liver. Eur. J. Biochem. 183(3), 661-669 (1989).