Berteroin

Berteroin is a sulforaphane (Item No. 10496) analog found in cruciferous vegetables including Chinese cabbage, rucola salad leaves, and mustard oil.¹ At 1.7 µM, it has been shown to double the phase II enzyme quinone reductase activity in mouse hepatoma cells.² Berteroin exerts anti-inflammatory activity in LPS-stimulated RAW 264.7 macrophages, inhibiting degradation of IκBα, as well as NF-κB p65 translocation to the nucleus and DNA binding activity.¹ It also suppresses IRAK degradation and phosphorylation of TAK1, p38 MAPK, ERK1/2, and Akt.¹

WARNING This product is not for human or veterinary use.

1. Jung, Y.J., Jung, J.I., Cho, H.J., et al. Berteroin present in cruciferous vegetables exerts potent anti-inflammatory properties in murine macrophages and mouse skin. Int. J. Mol. Sci. 15(11), 20686-20705 (2014).

2. Zhang, Y., Talalay, P., Cho, C.G., et al. A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure. Proc. Natl. Acad. Sci. USA 89(6), 2399-2403 (1992).