An endogenous fatty acid ester
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2-Palmitoyl Glycerol

Item No. 17882

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-1-(hydroxymethyl)ethyl ester hexadecanoic acid
CAS Number
23470-00-0
Synonyms
  • Glycerol-β-palmitate
  • 2-Hexadecanoyl Glycerol
  • 2-Monopalmitin
  • 2-PG
Molecular Formula
C19H38O4
Formula Weight
330.5
Purity
≥95% (85:15 mixture of the 2-PG and 1-PG)
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/ml
SMILES
CCCCCCCCCCCCCCCC(OC(CO)CO)=O
InChi Code
InChI=1S/C19H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(22)23-18(16-20)17-21/h18,20-21H,2-17H2,1H3
InChi Key
BBNYCLAREVXOSG-UHFFFAOYSA-N
Side Chain Carbon Sum
16:0
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $49

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    10 mg

    $77

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    25 mg

    $178

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    50 mg

    $329

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    Product Description

    2-Arachidonoyl glycerol (2-AG; Item No. 62160) is an endogenous agonist of the CB1 and CB2 cannabinoid receptors. 2-Palmitoyl glycerol is a fatty acid ester that does not bind directly to cannabinoid receptors, nor inhibit adenylyl cyclase, but rather potentiates the activity of 2-AG (and other endocannabinoids) to bind to CB1 and CB2 and inhibit adenylyl cyclase.1 This “entourage” effect has been attributed to blockade of the breakdown and reuptake pathways that normally function to reduce endocannabinoid levels rapidly upon release.1 2-Palmitoyl glycerol and related endogenous fatty acid derivatives have been shown to interact with endocannabinoids in the modulation of pain sensitivity.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ben-Shabat, S., Fride, E., Sheskin, T., et al. An entourage effect: Inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. Eur. J. Pharmacol. 353(1), 23-31 (1998).

    2. Walker, J.M., Krey, J.F., Chu, C.J., et al. Endocannabinoids and related fatty acid derivatives in pain modulation. Chem. Phys. Lipids 121(1-2), 159-172 (2002).