An inhibitor of H+/K+-ATPases
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SCH 28080

Item No. 17885

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-methyl-8-(phenylmethoxy)-imidazo[1,2-a]pyridine-3-acetonitrile
CAS Number
76081-98-6
Molecular Formula
C17H15N3O
Formula Weight
277.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/mlEthanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
229, 235, 280 nm
SMILES
CC1=C(CC#N)N(C2=N1)C=CC=C2OCC3=CC=CC=C3
InChi Code
InChI=1S/C17H15N3O/c1-13-15(9-10-18)20-11-5-8-16(17(20)19-13)21-12-14-6-3-2-4-7-14/h2-8,11H,9,12H2,1H3
InChi Key
PYKJFEPAUKAXNN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $110

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    10 mg

    $186

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    50 mg

    $835

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    Product Description

    SCH 28080 is a reversible K+-competitive inhibitor of H+/K+-ATPases that is best known for its ability to block acid secretion through its action against the gastric H+/K+-ATPase (IC50 = 1.3 µM).1,2,3 It is effective against gastric H+/K+-ATPases from a variety of species and can inhibit colonic H+/K+-ATPases, but this activity appears to be species-dependent.4 SCH 28080 is also used to investigate the role of H+/K+-ATPases in non-mammalian organisms and to distinguish the actions of H+/K+-ATPases from other ATP-dependent transporters.5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Beil, W., Hackbarth, I., and Sewing, K.F. Mechanism of gastric antisecretory effect of SCH 28080. Br. J. Pharmacol. 88(1), 19-23 (1986).

    2. Wallmark, B., Briving, C., Fryklund, J., et al. Inhibition of gastric H+,K+-ATPase and acid secretion by SCH 28080, a substituted pyridyl(1,2α)imidazole. The Journal of Biological Chemisty 262(5), 2077-2084 (1987).

    3. Swarts, H.G.P., Hermsen, H.P.H., Koenderink, J.B., et al. Conformation-dependent inhibition of gastric H+,K+-ATPase by SCH 28080 demonstrated by mutagenesis of glutamic acid 820. Mol. Pharmacol. 55(3), 541-547 (1999).

    4. Shao, J., Gumz, M.L., Cain, B.D., et al. Pharmacological profiles of the murine gastric and colonic H,K-ATPases. Biochim. Biophys. Acta 1800(9), 906-911 (2010).

    5. Beane, W.S., Morokuma, J., Adams, D.S., et al. A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration. Chem. Biol. 18(1), 77-89 (2011).

    6. Salyer, S.A., Olderding, J.R., Distler, A.A., et al. Vacuolar ATPase driven potassium transport in highly metastatic breast cancer cells. Biochim. Biophys. Acta 1832(10), 1734-1743 (2013).