A diuretic and antihypertensive agent
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Analytical Standard(s)
26300Chlorothiazide
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Chlorothiazide

Item No. 17909

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide, 1,1-dioxide
CAS Number
58-94-6
Synonyms
  • Diuril
  • NSC 25693
Molecular Formula
C7H6ClN3O4S2
Formula Weight
295.7
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 20 mg/ml
λmax
226, 279 nm
SMILES
O=S1(C2=CC(S(N)(=O)=O)=C(Cl)C=C2N=CN1)=O
InChi Code
InChI=1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)
InChi Key
JBMKAUGHUNFTOL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

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    5 g

    $95

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    10 g

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    Product Description

    Chlorothiazide is a first-in-class thiazide diuretic initially discovered from its ability to inhibit carbonic anhydrase in vitro.1 As an antihypertensive agent, this thiazide increases renal excretion of sodium, potassium, chloride, and bicarbonate ions by inhibiting tubular reabsorptive mechanisms.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Laragh, J.H. The mode of action and use of chlorothiazide and related compounds. Circulation 26, 121-132 (1962).