A muscarinic receptor agonist
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Aceclidine (hydrochloride)

Item No. 17910

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-azabicyclo[2.2.2]octan-3-ol, 3-acetate, monohydrochloride
CAS Number
6109-70-2
Molecular Formula
C9H15NO2 • HCl
Formula Weight
205.7
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
CC(OC1C(CC2)CCN2C1)=O.Cl
InChi Code
InChI=1S/C9H15NO2.ClH/c1-7(11)12-9-6-10-4-2-8(9)3-5-10;/h8-9H,2-6H2,1H3;1H
InChi Key
LWWSARSTZGNKGV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $36

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    500 mg

    $153

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    1 g

    $268

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    Product Description

    Aceclidine is an agonist of muscarinic receptors (EC50 = 1.8-17 µM for human M2).1 It induces contraction of iris sphincter muscle, resulting in miosis.2,3 Aceclidine has applications in glaucoma therapy and in basic research regarding muscarinic receptor signaling.1,2,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Griffin, M.T., Figueroa, K.W., Liller, S., et al. Estimation of agonist activity at G protein-coupled receptors: analysis of M2 muscarinic receptor signaling through Gi/o,Gs, and G15. J. Pharmacol. Exp. Ther. 321(3), 1193-1207 (2007).

    2. Ishikawa, H., Desantis, L., and Patil, P.N. Selectivity of muscarinic agonists including (+/-)-aceclidine andantimuscarinics on the human intraocular muscles. J. Ocul. Pharmacol. Ther. 14(4), 363-373 (1998).

    3. Smith, S.A., and Smith, S.E. Factors determining the potency of cholinomimetic miotic drugs and their effect upon the light reflex in man. Br. J. Clin. Pharmac. 6, 149-153 (1978).

    4. Shannon, H.E., Hart, J.C., Bymaster, F.P., et al. Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats. J. Pharmacol. Exp. Ther. 290(2), 901-907 (1999).