Pricing updated 2019-07-17. Prices are subject to change without notice.
Naringenin (Item No. 14173) is a citrus-derived flavonoid that inhibits cytochrome P450 (CYP) 3A4 activity in human liver microsomes (IC50s = 139-188 μM).1,2 Naringin is a natural flavanone glycoside formed from naringenin and neohesperidose. It undergoes extensive metabolism in the liver, giving rise to naringenin and other bioactive metabolites that have anti-oxidant, anti-inflammatory, and anti-apoptotic effects.3 Naringin is a weak inhibitor of CYP3A4, providing 14% inhibition at 200 µM.2 It suppresses apoptosis in neurons and increases the expression of neurotrophic factor in dopaminergic neurons, providing neuroprotection.4
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1. Fuhr, U., Klittich, K., and Staib, A.H. Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man British Journal of Clinical Pharmacology 35(4), 431-436 (1993).
2. Ho, P.C., and Saville, D.J. Inhibition of human CYP3A4 activity by grapefruit flavonoids, furanocoumarins and related compounds Journal of Pharmacy & Pharmaceutical Sciences 4(3), 217-227 (2001).
3. Bharti, S., Rani, N., Krishnamurthy, B., et al. Preclinical evidence for the pharmacological actions of naringin: A review Planta.Med. 80, 437-451 (2014).
4. Jung, U.J., Leem, E., and Kim, S.R. Naringin: A protector of the nigrostriatal dopaminergic projection Exp.Neurobiol. 23(2), 124-129 (2014).