An H-PGDS inhibitor
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TFC 007

Item No. 17971

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[4-(4-morpholinylcarbonyl)-1-piperidinyl]phenyl]-2-phenoxy-5-pyrimidinecarboxamide
CAS Number
927878-49-7
Molecular Formula
C27H29N5O4
Formula Weight
487.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 1 mg/mlEthanol: insolPBS (pH 7.2): insol
λmax
218, 311 nm
SMILES
O=C(NC1=CC=C(N2CCC(C(N3CCOCC3)=O)CC2)C=C1)C(C=N4)=CN=C4OC5=CC=CC=C5
InChi Code
InChI=1S/C27H29N5O4/c33-25(21-18-28-27(29-19-21)36-24-4-2-1-3-5-24)30-22-6-8-23(9-7-22)31-12-10-20(11-13-31)26(34)32-14-16-35-17-15-32/h1-9,18-20H,10-17H2,(H,30,33)
InChi Key
NLSSUSRERAMBTA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    TFC 007 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50 = 0.083 µM).1 It is selective for H-PGDS over lipocalin PGDS (L-PGDS) and microsomal PGE2 synthase (mPGES) at 100 µM. It is also selective for H-PGDS over COX-1, COX-2, 5-lipoxygenase (5-LO), leukotriene C4 (LTC4) synthase, and thromboxane (TX) synthase, as well as the histamine H1 and cysteinyl leukotriene 1 (CysLT1) receptors, at 10 µM. TFC 007 (30 mg/kg) inhibits antigen-induced increases in the production of PGD2 (Item No. 12010) in nasal cavity lavage fluid and reduces nasal blockage in a guinea pig model of allergic rhinitis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nabe, T., Kuriyama, Y., Mizutani, N., et al. Inhibition of hematopoietic prostaglandin D synthase improves allergic nasal blockage in guinea pigs. Prostaglandins Other Lipid Mediat. 95(1-4), 27-34 (2011).