An allosteric inhibitor of oncogenic K-Ras(G12C)
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6H05 (trifluoroacetate salt)

Item No. 17985

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[2-[(4-chlorophenyl)thio]acetyl]-N-[2-[[2-(dimethylamino)ethyl]dithio]ethyl]- 4-piperidinecarboxamide, trifluoroacetate salt
CAS Number
2061344-88-3
Molecular Formula
C20H30ClN3O2S3 • CF3COOH
Formula Weight
590.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMSO: 30 mg/mLEthanol: 25 mg/mLPBS (pH 7.2): 10 mg/mL
λmax
259 nm
SMILES
ClC1=CC=C(SCC(N2CCC(C(NCCSSCCN(C)C)=O)CC2)=O)C=C1.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C20H30ClN3O2S3.C2HF3O2/c1-23(2)12-14-29-28-13-9-22-20(26)16-7-10-24(11-8-16)19(25)15-27-18-5-3-17(21)4-6-18;3-2(4,5)1(6)7/h3-6,16H,7-15H2,1-2H3,(H,22,26);(H,6,7)
InChi Key
YNMYIJSFFJXIRV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $238

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    10 mg

    $367

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    25 mg

    $653

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    Product Description

    6H05 is a small molecule that allosterically binds to a mutant cysteine on oncogenic K-Ras(G12C), thus inhibiting its function.1 Binding of 6H05 to K-Ras(G12C) disrupts both switch-I and switch-II, altering the native nucleotide preference to favor GDP over GTP, which impedes binding to Raf.1 Because 6H05 is selective for mutant Cys-12, it does not affect wild-type K-Ras.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ostrem, J.M., Peters, U., Sos, M.L., et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 503(7477), 548-551 (2013).