A subunit-selective NMDA receptor potentiator
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CIQ

Item No. 17997

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3-chlorophenyl)[3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]-methanone
CAS Number
486427-17-2
Molecular Formula
C26H26ClNO5
Formula Weight
467.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMF:PBS (pH 7.2) (1:4): 0.2 mg/mLDMSO: 25 mg/mLEthanol: 0.2 mg/mL
λmax
284 nm
SMILES
COC1=CC=C(OCC2N(C(C3=CC(Cl)=CC=C3)=O)CCC4=C2C=C(OC)C(OC)=C4)C=C1
InChi Code
InChI=1S/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
InChi Key
VYMILMYEENZHAR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    CIQ is a substituted tetrahydroisoquinoline that acts as a subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.1 It is without effect at subunits NR2A, NR2B, or glutamate receptors. CIQ enhances receptor responses two-fold (EC50 = 3 µM) by increasing channel opening frequency for glutamate or glycine.1 It is a positive allosteric modulator that does not alter agonist EC50 values.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mullasseril, P., Hansen, K.B., Vance, K.M., et al. A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. Nat. Commun. 1:90, (2010).

    2. Monaghan, D.T., Irvine, M.W., Costa, B.M., et al. Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators. Neurochem Int. 61(4), 581-592 (2012).

    3. Hackos, D.H., and Hanson, J.E. Diverse modes of NMDA receptor positive allosteric modulation: Mechanisms and consequences. Neuropharmacology 112(Pt A), 34-45 (2017).