DY 131

DY 131 is a selective agonist of the ERRβ/γ receptor (EC₅₀ = 130 nM).^1,2 It does not affect the ERRα receptor nor the ERs α and β at concentrations up to 30 µM.^1,2 DY 131 has been used to potentiate ERRγ-induced growth inhibition in LNCaP and DU145 prostate cancer cell lines in order to demonstrate an antiproliferative/tumor-suppressing function for ERRγ in prostate cancer.³

WARNING This product is not for human or veterinary use.

1. Zuercher, W.J., Gaillard, S., Orband-Miller, L.A., et al. Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRβ and ERRγ. J. Med. Chem. 49(9), 3107-3109 (2005).

2. Yu, D.D., and Forman, B.M. Identification of an agonist ligand for estrogen-related receptors ERRβ/γ. Bioorg. Med. Chem. Lett. 15(5), 1311-1313 (2005).

3. Yu, S., Wang, X., Ng, C.F., et al. ERRγ suppresses cell proliferation and tumor growth of androgen-sensitive and androgen-insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancer. Cancer Res. 67(10), 4904-4914 (2007).