An ERRβ/γ agonist
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DY 131

Item No. 17999

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-hydroxy-benzoic acid 2-[[4-(diethylamino)phenyl]methylene]hydrazide
CAS Number
95167-41-2
Synonyms
  • GSK9089
Molecular Formula
C18H21N3O2
Formula Weight
311.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 3 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
λmax
247, 363 nm
SMILES
OC1=CC=C(C(N/N=C/C2=CC=C(N(CC)CC)C=C2)=O)C=C1
InChi Code
InChI=1S/C18H21N3O2/c1-3-21(4-2)16-9-5-14(6-10-16)13-19-20-18(23)15-7-11-17(22)12-8-15/h5-13,22H,3-4H2,1-2H3,(H,20,23)/b19-13+
InChi Key
WLKOCYWYAWBGKY-CPNJWEJPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $68

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    10 mg

    $118

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    25 mg

    $258

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    50 mg

    $451

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    Cayman Chemical
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    Product Description

    DY 131 is a selective agonist of the ERRβ/γ receptor (EC50 = 130 nM).1,2 It does not affect the ERRα receptor nor the ERs α and β at concentrations up to 30 µM.1,2 DY 131 has been used to potentiate ERRγ-induced growth inhibition in LNCaP and DU145 prostate cancer cell lines in order to demonstrate an antiproliferative/tumor-suppressing function for ERRγ in prostate cancer.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zuercher, W.J., Gaillard, S., Orband-Miller, L.A., et al. Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRβ and ERRγ. J. Med. Chem. 49(9), 3107-3109 (2005).

    2. Yu, D.D., and Forman, B.M. Identification of an agonist ligand for estrogen-related receptors ERRβ/γ. Bioorg. Med. Chem. Lett. 15(5), 1311-1313 (2005).

    3. Yu, S., Wang, X., Ng, C.F., et al. ERRγ suppresses cell proliferation and tumor growth of androgen-sensitive and androgen-insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancer. Cancer Res. 67(10), 4904-4914 (2007).