A growth hormone secretagogue and ghrelin receptor agonist
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Analytical Standard(s)
44475Ibutamoren
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Ibutamoren (mesylate)

Item No. 18003

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4'-piperidin]-1'-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methyl-propanamide, methanesulfonate
CAS Number
159752-10-0
Synonyms
  • L-163,191
  • MK-0677
Molecular Formula
C27H36N4O5S • CH3SO3H
Formula Weight
624.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
232, 280 nm
SMILES
O=C(N1CCC2(C(C=CC=C3)=C3N(S(C)(=O)=O)C2)CC1)[C@H](NC(C(C)(N)C)=O)COCC4=CC=CC=C4.OS(=O)(C)=O
InChi Code
InChI=1S/C27H36N4O5S.CH4O3S/c1-26(2,28)25(33)29-22(18-36-17-20-9-5-4-6-10-20)24(32)30-15-13-27(14-16-30)19-31(37(3,34)35)23-12-8-7-11-21(23)27;1-5(2,3)4/h4-12,22H,13-19,28H2,1-3H3,(H,29,33);1H3,(H,2,3,4)/t22-;/m1./s1
InChi Key
DUGMCDWNXXFHDE-VZYDHVRKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Product Description

    Ghrelin is an endogenous ligand for the growth hormone (GH) secretagogue receptor (GHSR).1 Ibutamoren is an orally-active, non-peptidic agonist of GHSR (Kd = 0.4 nM) and, as a result, is a GH secretagogue.2,3 It elevates GH in dogs after oral doses as low as 0.125 mg/kg, without significantly changing plasma levels of aldosterone, luteinizing hormone, thyroxine, or prolactin.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kojima, M., Hosoda, H., Date, Y., et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402(6762), 656-660 (1999).

    2. Howard, A.D., Feighner, S.D., Cully, D.F., et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273(5277), 974-977 (1996).

    3. Smith, R.G., Pong, S.S., Hickey, G., et al. Modulation of pulsatile GH release through a novel receptor in hypothalamus and pituitary gland. Recent Prog. Horm. Res. 51, 261-286 (1996).

    4. Patchett, A.A., Nargund, R.P., Tata, J.R., et al. Design and biological activities of L-163,191 (MK-0677): A potent, orally active growth hormone secretagogue. Proc. Natl. Acad. Sci. USA 92(15), 7001-7005 (1995).