A stabilizer of G-quadruplexes
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Pyridostatin (trifluoroacetate salt)

Item No. 18013

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2-aminoethoxy)-N2,N6-bis[4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinedicarboxamide, trifluoroacetate salt
CAS Number
1472611-44-1
Molecular Formula
C31H32N8O5 • C2HF3O2
Formula Weight
710.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
228, 269, 311, 324 nm
SMILES
NCCOC1=CC(NC(C2=NC(C(NC3=CC(OCCN)=C4C=CC=CC4=N3)=O)=CC(OCCN)=C2)=O)=NC5=C1C=CC=C5.FC(F)(F)C(O)=O
InChi Code
InChI=1S/C31H32N8O5.C2HF3O2/c32-9-12-42-19-15-24(30(40)38-28-17-26(43-13-10-33)20-5-1-3-7-22(20)36-28)35-25(16-19)31(41)39-29-18-27(44-14-11-34)21-6-2-4-8-23(21)37-29;3-2(4,5)1(6)7/h1-8,15-18H,9-14,32-34H2,(H,36,38,40)(H,37,39,41);(H,6,7)
InChi Key
AOHXRDMGALEMBB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

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    10 mg

    $236

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    25 mg

    $544

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    Cayman Chemical
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    Product Description

    Pyridostatin is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres. It can compete for binding with the telomere-associated proteins and induce telomerase dysfunction. Pyridostatin induces DNA damage and cell cycle arrest (Kd = 490 nM) and has been shown to target the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rodriguez, R., Miller, K.M., Forment, J.V., et al. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat. Chem. Biol. 8(3), 301-310 (2012).