A natural polyamine
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Spermine

Item No. 18041

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1,N4-bis(3-aminopropyl)-1,4-butanediamine
CAS Number
71-44-3
Synonyms
  • Gerontine
  • Musculamine
  • Neuridine
  • NSC 268508
  • 1,5,10,14-Tetraazatetradecane
Molecular Formula
C10H26N4
Formula Weight
202.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Water: 50 mg/ml
SMILES
NCCCNCCCCNCCCN
InChi Code
InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
InChi Key
PFNFFQXMRSDOHW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 g

    $41

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    5 g

    $128

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    10 g

    $178

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    25 g

    $341

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    Product Description

    Spermine is an endogenous polyamine synthesized from the reaction of spermidine (Item No. 14918) with decarboxylated S-adenosylmethionine in the presence of the enzyme spermine synthase and is required for eukaryotic cell growth and protein synthesis.1,2 Intracellular spermine blocks inward rectifying K+ channels, whereas extracellular spermine acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site.3 Spermine has neuroprotective and anti-inflammatory effects and functions as a free radical scavenger to prevent DNA damage by reactive oxygen species.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wallace, H.M., Fraser, A.V., and Hughes, A. A perspective of polyamine metabolism. Biochem. J. 376(Pt 1), 1-14 (2003).

    2. Igarashi, K., and Kashiwagi, K. Polyamines: Mysterious modulators of cellular functions. Biochem. Biophys. Res. Commun. 271(3), 559-564 (2000).

    3. Williams, K. Interactions of polyamines with ion channels. Biochem J. 325(Pt 2_, 289-297 (1997).

    4. Ha, H.C., Sirisoma, N.S., Kuppusamy, P., et al. The natural polyamine spermine functions directly as a free radical scavenger. Proc. Natl. Acad. Sci. USA 95(19), 11140-11145 (1998).