An inhibitor of PDE7
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2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide

Item No. 18085

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-[(5-chloro-2-nitrophenyl)thio]phenyl]-acetamide
CAS Number
107522-19-0
Synonyms
  • 2'-(5-chloro-2-nitrophenylthio)-Acetanilide
Molecular Formula
C14H11ClN2O3S
Formula Weight
322.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 5 mg/ml
λmax
244, 363 nm
SMILES
ClC1=CC(SC2=CC=CC=C2NC(C)=O)=C([N+]([O-])=O)C=C1
InChi Code
InChI=1S/C14H11ClN2O3S/c1-9(18)16-11-4-2-3-5-13(11)21-14-8-10(15)6-7-12(14)17(19)20/h2-8H,1H3,(H,16,18)
InChi Key
LAFNJWWMXIXPJF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    2-Acetamidophenyl 5-chloro-2-nitrophenyl sulfide is a sulfide-like inhibitor of phosphodiesterase 7 (PDE7; IC50 = 2.1 µM).1 It is selective for PDE7A, producing only 10-11% inhibition of PDE3A, PDE4D, and PDE4B at 10 µM.1 It also has no antioxidant activity or inhibitory activity against a panel of protein kinases.1 Sulfide-like PDE7 inhibitors derived from 2-acetamidophenyl 5-chloro-2-nitrophenyl sulfide have cytoprotective and anti-inflammatory effects on SH-SY5Y neuroblastoma cells without action in a surrogate emesis mouse model.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. García, A.M., Brea, J., Morales-Garcia, J.A., et al. Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors. J. Med. Chem. 57(20), 8590-8607 (2014).