A potent inhibitor of ADP-induced platelet aggregation
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6α-Prostaglandin I1

Item No. 18110

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6R,9α-epoxy-11α,15S-dihydroxy-prost-13E-en-1-oic acid
CAS Number
62777-90-6
Synonyms
  • 6α-PGI1
  • 5,6α-dihydro PGI2
Molecular Formula
C20H34O5
Formula Weight
354.5
Purity
≥99%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: >10 mg/mlDMSO: >5 mg/mlEthanol: >20 mg/mlPBS (pH 7.2): >80 µg
SMILES
O[C@H]1[C@H](/C=C/[C@@H](O)CCCCC)[C@@H](C[C@](CCCCC(O)=O)([H])O2)[C@@H]2C1
InChi Code
InChI=1S/C20H34O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h10-11,14-19,21-22H,2-9,12-13H2,1H3,(H,23,24)/b11-10+/t14-,15+,16+,17+,18+,19-/m0/s1
InChi Key
RJADQDXZYFCVHV-WDONHGPHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $71

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    5 mg

    $308

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    10 mg

    $547

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    Product Description

    6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. 6α-PGI1 promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration dependent manner. However, it is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI2 in eliciting the response.1 6α-PGI1 exhibits an IC50 of 350 ng/ml for inhibition of ADP-induced platelet aggregation, which is nearly 900-fold higher than that observed for PGI2 (0.4 ng/ml).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Patrono, C., Rotella, C.M., Toccafondi, R.S., et al. Prostacyclin stimulates the adenylate cyclase system of human thyroid tissue. Prostaglandins 22(1), 105-115 (1981).

    2. Whittle, B.J.R., and Moncada, S. Prostacyclin and its analogues for the therapy of thromboembolic disorders. Adv. Exp. Med. Biol. 164, 193-209 (1984).