A selective SIRT2 inhibitor
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SirReal2

Item No. 18116

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]-acetamide
CAS Number
709002-46-0
Molecular Formula
C22H20N4OS2
Formula Weight
420.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 3 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
λmax
247, 282 nm
SMILES
CC1=NC(SCC(NC2=NC=C(CC3=C(C=CC=C4)C4=CC=C3)S2)=O)=NC(C)=C1
InChi Code
InChI=1S/C22H20N4OS2/c1-14-10-15(2)25-22(24-14)28-13-20(27)26-21-23-12-18(29-21)11-17-8-5-7-16-6-3-4-9-19(16)17/h3-10,12H,11,13H2,1-2H3,(H,23,26,27)
InChi Key
MENNDDDTIIZDDN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $128

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    10 mg

    $196

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    50 mg

    $873

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    Product Description

    SirReal2 is an aminothiazole that acts as a SIRT-rearranging ligand to selectively inhibit SIRT2 (IC50 = 140 nM).1 SirReal2 is >1,000-fold more potent at inhibiting the activity of SIRT2 than that of SIRT1 or SIRT3-6.1 This compound has been shown to be active in HeLa cells by significantly increasing α-tubulin acetylation.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rumpf, T., Schiedel, M., Karaman, B., et al. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. Nat. Commun. 6, (2015).