A stable PGI2 analog with reduced potency
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6β-Prostaglandin I1

Item No. 18120

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6S,9α-epoxy-11α,15S-dihydroxy-prost-13E-en-1-oic acid
CAS Number
62770-50-7
Synonyms
  • 6β-PGI1
  • 5,6β-dihydro PGI2
Molecular Formula
C20H34O5
Formula Weight
354.5
Purity
≥99%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: >10 mg/mlDMSO: >5 mg/mlEthanol: >20 mg/mlPBS pH 7.2: >80 µg/ml
SMILES
CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C[C@@](CCCCC(O)=O)([H])O2
InChi Code
InChI=1S/C20H34O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h10-11,14-19,21-22H,2-9,12-13H2,1H3,(H,23,24)/b11-10+/t14-,15-,16+,17+,18+,19-/m0/s1
InChi Key
RJADQDXZYFCVHV-CBIPHORWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6β-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6β-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 µM compared with 18 nM for PGI2. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI2.1,2

    WARNING This product is not for human or veterinary use.