A selective MTH1 inhibitor
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TH287

Item No. 18132

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(2,3-dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine
CAS Number
1609960-30-6
Molecular Formula
C11H10Cl2N4
Formula Weight
269.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mLDMF:PBS(pH 7.2)(1:1): 0.5 mg/mLDMSO: 20 mg/mLEthanol: 2 mg/mL
λmax
294 nm
SMILES
CNC1=CC(C2=CC=CC(Cl)=C2Cl)=NC(N)=N1
InChi Code
InChI=1S/C11H10Cl2N4/c1-15-9-5-8(16-11(14)17-9)6-3-2-4-7(12)10(6)13/h2-5H,1H3,(H3,14,15,16,17)
InChi Key
URWCXPXBBITYLR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $120

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    10 mg

    $167

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    Cayman Chemical
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    Product Description

    TH287 is an MTH1 inhibitor (IC50 = 0.8 nM) that selectively kills cancer cell lines (IC50s = 0.8-3.06 µM) without significant cytotoxicity towards primary or immortalized cells (IC50s = ≥20 µM).1 At up to 100 µM it does not show significant effect towards the related nudix hydrolase protein family members MTH2, NUDT5, NUDT12, NUDT14, and NUDT16, as well as other proteins with known nucleoside triphosphate pyrophosphatase activity (dCTPase, dUTPase, and ITPA).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gad, H., Koolmeister, T., Jemth, A.S., et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature 508, 215-242 (2014).