A pyrimidine nucleoside triphosphate
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Cytidine 5'-triphosphate (sodium salt hydrate)

Item No. 18147

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
cytidine 5'-(tetrahydrogen triphosphate), disodium salt, hydrate
CAS Number
652154-13-7
Synonyms
  • CTP
  • NSC 20261
Molecular Formula
C9H14N3O14P3 • 2Na [XH2O]
Formula Weight
527.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
275 nm
SMILES
O=P(OP(OP(O)([O-])=O)(O)=O)([O-])OC[C@H]1O[C@@H](N2C(N=C(N)C=C2)=O)[C@H](O)[C@@H]1O.[Na+].[Na+].O
InChi Code
InChI=1S/C9H16N3O14P3.2Na.H2O/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18);;;1H2/q;2*+1;/p-2/t4-,6-,7-,8-;;;/m1.../s1
InChi Key
IJMSOWKYYIROGP-LLWADOMFSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Cytidine 5'-triphosphate (CTP) is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. It is used in the synthesis of RNA by RNA polymerases. In the formation of phosphatidylcholine (PC), CTP reacts with phosphocholine, via CTP:phosphocholine cytidylyltransferases, to produce CDP-choline and diphosphate.1,2 This is the rate-limiting step in PC synthesis and, as a pivotal step in cell proliferation, can be important in cancer.3 CTP also interacts with N-acylneuraminate, in a reaction mediated by N-acylneuraminate cytidylyltransferase, to generate an intermediate that is required for sialylation, namely CMP-N-acylneuraminic acid.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, Z., and Vance, D.E. Phosphatidylcholine and choline homeostasis. J. Lipid Res. 49(6), 1187-1194 (2008).

    2. Lagace, T.A., and Ridgway, N.D. The role of phospholipids in the biological activity and structure of the endoplasmic reticulum. Biochim. Biophys. Acta 1833(11), 2499-2510 (2013).

    3. Arsenault, D.J., Yoo, B.H., Rosen, K.V., et al. ras-Induced up-regulation of CTP:phosphocholine cytidyltransferase a contributes to malignant transformation of intestinal epithelial cells. The Journal of Biological Chemisty 288(1), 633-643 (2013).

    4. Vionnet, J., Concepcion, N., Warner, T., et al. Purification of CMP-N-acetylneuraminic acid synthetase from bovine anterior pituitary glands. Glycobiology 9(5), 481-487 (1999).