A brominated derivative of guanosine
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

8-Bromoguanosine

Item No. 18152

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-bromo-guanosine
CAS Number
4016-63-1
Synonyms
  • 2-Amino-8-bromo-6-hydroxypurine riboside
  • NSC 79211
  • NSC 174257
Molecular Formula
C10H12BrN5O5
Formula Weight
362.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 20 mg/ml
λmax
261 nm
SMILES
O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C(Br)=N2)N=C(N)N1
InChi Code
InChI=1S/C10H12BrN5O5/c11-9-13-3-6(14-10(12)15-7(3)20)16(9)8-5(19)4(18)2(1-17)21-8/h2,4-5,8,17-19H,1H2,(H3,12,14,15,20)/t2-,4-,5-,8-/m1/s1
InChi Key
ASUCSHXLTWZYBA-UMMCILCDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 g

    $36

    Add

    5 g

    $62

    Add

    10 g

    $103

    Add

    25 g

    $209

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    8-Bromoguanosine is a brominated derivative of guanosine. Purine nucleobases with bromine at position eight are known to preferentially adopt the syn conformation as nucleosides and, thus, can be used to reduce the conformational heterogeneity of RNA to potentially enhance its function.1 It is reported to activate lymphocytes through an intracellular mechanism to exert immunostimulatory effects.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yajima, R., Proctor, D.J., Kierzek, R., et al. A conformationally restricted guanosine analog reveals the catalytic relevance of three structures of an RNA enzyme. Chem. Biol. 14, 23-30 (2007).

    2. Goodman, M.G., and Weigle, W.O. Intracellular lymphocyte activation and carrier-mediated transport of C8-substituted guanine ribonucleosides. Proc. Natl. Acad. Sci. USA 81, 862-866 (1984).

    3. Giorgio, S., and Barao, S.C. Intracellular Leishmania amazonensis killing induced by the guanine nucleoside 8-bromoguanosine. Rev. Inst. Med. Trop. Sao Paulo 40(4), 237-240 (1998).