A modified purine of microbial genomes
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N6-Methyladenine

Item No. 18153

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-9H-purin-6-amine
CAS Number
443-72-1
Synonyms
  • NSC 11580
Molecular Formula
C6H7N5
Formula Weight
149.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 1 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 2 mg/ml
λmax
210, 265 nm
SMILES
CNC(NC=N1)=C2C1=NC=N2
InChi Code
InChI=1S/C6H7N5/c1-7-5-4-6(10-2-8-4)11-3-9-5/h2-3H,1H3,(H2,7,8,9,10,11)
InChi Key
CKOMXBHMKXXTNW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $54

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    100 mg

    $96

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    250 mg

    $209

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    500 mg

    $315

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    Product Description

    N6-Methyladenine is a modified purine that is commonly found in genomes of prokaryotes, protists, and plants.1,2 It is less common in higher eukaryotes and extremely rare in mammals.1,3 Like methylation of other DNA residues, N6-methyladenine represents an epigenetic modification that can affect diverse DNA functions, including replication, repair, and expression.1,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ratel, D., Ravanat, J.L., and Wion, D. N6-Methyladenine: The other methylated base of DNA. BioEssays 28(3), 309-315 (2006).

    2. Hattman, S. DNA-[adenine] methylation in lower eukaryotes. Biochem.(Moscow) 70(5), 550-558 (2005).

    3. Breiling, A., and Lyko, F. Epigenetic regulatory functions of DNA modifications: 5-Methylcytosine and beyond. Epigenetics Chromatin 8, 24 (2015).