A modified form of thymidine
Related Products
Isomer(s)
339393′-deoxy Thymidine
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Product Type

Biochemicals
Antibiotics

Research Area

5'-deoxy Thymidine

Item No. 18154

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5'-deoxy-thymidine
CAS Number
3458-14-8
Molecular Formula
C10H14N2O4
Formula Weight
226.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
CC1=CN(C(NC1=O)=O)[C@H]2C[C@H](O)[C@@H](C)O2
InChi Code
InChI=1S/C10H14N2O4/c1-5-4-12(10(15)11-9(5)14)8-3-7(13)6(2)16-8/h4,6-8,13H,3H2,1-2H3,(H,11,14,15)/t6-,7+,8-/m1/s1
InChi Key
UGUILUGCFSCUKR-GJMOJQLCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $236

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    Product Description

    5'-deoxy Thymidine is a form of thymidine in which the hydroxyl group on carbon 5 of ribose has been replaced with hydrogen. As a result, this compound cannot be phosphorylated and used by DNA polymerase in the synthesis of DNA. 5'-deoxy Thymidine is readily imported by cellular nucleoside importers and competitively inhibits the influx of thymidine.1 It demonstrates antibacterial activity against B. subtilis and S. aureus.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Domin, B.A., Mahony, W.B., Koszalka, G.W., et al. Membrane permeation characteristics of 5'-modified thymidine analogs. Mol. Pharmacol. 41(5), 950-956 (1992).

    2. Hatano, A., Nishimura, M., and Souta, I. Impact of unnatural nucleosides on the control of microbial growth. Biocontrol Science 14(2), 55-60 (2009).